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Gautam Vivek Soni
Associate Professor
Office : 948083 6140
Email : gvsoni
Webpage : https://sites.google.com/site/gvsonilab/
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My lab's work is primarily guided by the question of fundamental synergy of structures in biological systems and their functional dynamics. In their native state, genomes of all eukaryotic organisms are folded into complex higher-order structures. Given its role in regulating all DNA and chromosome dependent processes, a major goal has been to elucidate physical mechanisms involved in folding of chromatin into highly compact higher order structures. Small changes in chromatin fibers yield dramatic effects in its large-scale organization and hence drastic biological implications.

We develop novel nanotechnological tools to decipher physical rules governing self-assembled proteins and DNA-protein complexes in biological cells. These biophysical principles and their interdisciplinary approach are specially of interest as they lead to better understanding of cell function as well as diseases. In our lab, we study multi-scale chromatin structure and its epigenomic gene regulatory implications. Specifically, how the physical interactions leading to chromatin structure control biological processes?

Our lab's research involves exploring, at a single-molecule level, the forces and dynamics of chromatin compaction and its modulation by architectural proteins. This research is essential to help us understand how chromatin structure, DNA repair and cellular aging gets regulated and to provide insight into why diseases like cancer occur.
Selected publications -
1 Periodic Modulations of Optical Tweezers Near Solid-state Membranes.
G.V. Soni, M. Jonsson & Cees Dekker,
Small (2013) 9(5):679-684.
2 Rapid manufacturing of low-noise membranes for nanopore sensors by trans-chip illumination lithography.
X. Janssen, M. Jonsson, C. Plesa, G.V. Soni, N.H. Dekker & C. Dekker, Nanotechnology (2012)23:475302.
3 Detection of Nucleosomal Substructures Using Solid-State Nanopores.
G.V. Soni & Cees Dekker.
Nanoletters (2012) 12:3180-6.
4 Synchronous Optical and Electrical Detection of Biomolecules Traversing Through Solid-State Nanopores.
G.V.Soni, A. Singer, Y. Sun, Z. Yu & A. Meller.
Rev.Sci. Instrum. (2010) 81: 014301
5 The Potential and Challenges of Nanopore Sequencing.
D. Branton,…, G.V. Soni, et.al. 
Nature Biotechnology. (2008) 26: 1146-1153.